Who is MAP6?
Microtubule-associated protein 6 (MAP6) or stable tubule-only polypeptide (STOP or STOP protein) is a protein that in humans is encoded by the MAP6 gene. This gene encodes a microtubule-associated protein (MAP). The encoded protein is a calmodulin binding, and calmodulin-regulated protein that is involved in microtubule stabilization. MAP6 localization is present throughout neuronal maturation and axonal development. It protects microtubules under drug and cold induced depolymerization by reducing the shrinking rate and promoting rescue events. A deficit in MAP6 protein levels is characterized by behavioral impairments, most notably schizophrenia.
